Sam Darnold steered Seattle’s offense to an 82.6 PFF grade, the week's top Seahawk mark, defying San Francisco’s surge. He took what the Niners gave and played cleanly until a late fumble sealed the loss. Cooper Kupp’s Seahawks debut was blunt with two catches and a drop, dragging Seattle’s overall grade down. On defense, Josh Jobe and Ernest Jones posted the top Seahawk grades, while Ty Okada and Riq Woolen struggled in coverage as Purdy lit Seattle up with two interceptions baited by Jobe and Jones. Ricky Pearsall's late-game impact and Kittle’s TD highlighted SF’s edge in key moments. Seattle’s Week 1 showed a surprising offense floor with high-leverage playmaking, but execution and turnovers still defined the result.

The Seattle Seahawks will be without star receiver DK Metcalf for their matchup against the Buffalo Bills due to a Grade 1 MCL sprain. Coach Mike Macdonald had hoped Metcalf could test his knee before the game, but he ultimately did not participate. Seattle will rely on Jake Bobo, Laviska Shenault, and Dareke Young to fill the void left by Metcalf.

In addition, defensive tackle Cameron Young will also miss the game, leaving the Seahawks thin on the defensive line. Jarran Reed and Johnathan Hankins are expected to step up in his absence. The secondary will see the return of Riq Woolen and Tre Brown, while rookie Nehemiah Pritchett will miss his first game due to an ankle injury.